PT-141 (Bremelanotide) – 10MG Research-Use-Only Peptide
PT-141 is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), studied in laboratory settings as an agonist of the melanocortin-4 receptor (MC4-R). This product is provided in a 10 mg vial formulation intended solely for controlled research environments.
Research Context
Melanocortin receptors, including MC4-R, are G-protein coupled receptors studied extensively for their role in central signaling pathways. PT-141 is used in research settings as a tool compound to probe MC4-R activation and its downstream intracellular effects, distinct from the related MC1R-focused melanocortin analogs. As a well-characterized receptor agonist, PT-141 is frequently referenced in comparative melanocortin receptor pharmacology studies.
Research Overview
In preclinical and cell-based models, PT-141 has been studied for its receptor binding kinetics, cyclic AMP signaling activation, and downstream neuroendocrine pathway engagement. Research has also examined PT-141 in the context of cardiovascular parameter monitoring and feeding-behavior endpoint models in laboratory animal studies. These investigations remain exploratory, and mechanism-of-action findings should be treated as hypotheses under active study rather than settled conclusions.
Key Research Focus Areas
- Melanocortin-4 Receptor Agonism: Investigation of PT-141’s binding affinity and activation of MC4-R signaling cascades.
- Neuroendocrine Signaling: Examination of downstream hormone secretion patterns following MC4-R activation in preclinical models.
- Cardiovascular Parameter Research: Study of PT-141-associated changes in blood pressure and heart rate variability in animal research models.
- Feeding Behavior Endpoints: Use in laboratory models examining melanocortin pathway involvement in feeding and energy balance research.
- Comparative Melanocortin Pharmacology: Contrast with MC1R-selective analogs (such as Melanotan I/II) to clarify receptor selectivity and structure-function relationships.
Cautionary Statement
PT-141 is a research chemical and should only be handled by qualified personnel within approved academic or institutional research facilities. This product is not intended for human or animal consumption and poses significant risks if misused. Users must adhere to all applicable laboratory safety protocols, including proper disposal procedures for peptide waste. Always consult relevant institutional review boards and ethics committees prior to initiating research activities involving PT-141.
For research use only. Not for human or animal consumption.
