MT-1 (Melanotan I) – 10MG Research-Use-Only Peptide
MT-1, commonly referenced in research literature as Melanotan I, is a synthetic linear tridecapeptide analog of endogenous alpha-melanocyte-stimulating hormone (α-MSH). It is structurally related to afamelanotide and shares the core heptapeptide sequence responsible for melanocortin receptor engagement. This product is provided in a 10 mg vial formulation intended solely for controlled research environments.
Research Context
α-MSH and its synthetic analogs have been studied since the 1980s for their high-affinity interactions with melanocortin receptors, particularly MC1R, which is expressed on melanocytes. MT-1 was one of the earliest α-MSH analogs developed for laboratory investigation into melanocortin receptor pharmacology, and it remains a reference compound in structure-activity comparisons against later analogs. Researchers use MT-1 to probe receptor binding kinetics and downstream intracellular signaling independent of any applied or therapeutic context.
Research Overview
In cellular and preclinical models, MT-1 is studied as a nonselective melanocortin receptor agonist, with particular research interest in MC1R-mediated signal transduction. Investigations commonly examine receptor binding affinity, cyclic AMP (cAMP) accumulation, and downstream transcriptional activation of enzymes involved in melanin synthesis. As a well-characterized reference analog, MT-1 is frequently used alongside newer melanocortin peptides to contextualize structure-activity relationships.
Key Research Focus Areas
- Melanocortin Receptor Pharmacology: Investigation of MT-1 binding affinity and selectivity across melanocortin receptor subtypes, with emphasis on MC1R.
- Melanogenic Signaling Pathways: Study of cAMP-dependent activation of tyrosinase and related enzymes involved in melanin biosynthesis in cultured melanocyte models.
- Structure-Activity Relationships: Comparative analysis of MT-1 against α-MSH and later melanocortin analogs to clarify how sequence and cyclization influence receptor engagement.
- Cellular Pigmentation Models: Use in vitro melanocyte and keratinocyte co-culture systems to study pigment production dynamics.
- Receptor Desensitization Kinetics: Examination of MC1R internalization and downregulation patterns following prolonged agonist exposure in laboratory models.
Cautionary Statement
MT-1 is a research chemical and should only be handled by qualified personnel within approved academic or institutional research facilities. This product is not intended for human or animal consumption and poses significant risks if misused. Users must adhere to all applicable laboratory safety protocols, including proper disposal procedures for peptide waste. Always consult relevant institutional review boards and ethics committees prior to initiating research activities involving MT-1.
For research use only. Not for human or animal consumption.
